Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776816 | 0.82 | CD274 (0.53) | CD274PDCD1LG2 | |
| SCHEMBL23557741 | 0.71 | MTNR1A (0.33) | — | |
| SCHEMBL8041968 | 0.68 | SMN1; SMN2 (0.65) | DPP7LMNACHRM2POLBRAB9A | |
| SCHEMBL24722594 | 0.68 | CD274 (0.53) | CD274PDCD1LG2 | |
| SCHEMBL23198417 | 0.68 | CD274 (0.54) | CD274PDCD1LG2 | |
| SCHEMBL184001 | 0.67 | LMNA (0.77) | DPP7LMNACHRM2CYP3A4CYP2D6 | |
| SCHEMBL1796909 | 0.67 | LMNA (0.77) | DPP7LMNACHRM2CYP3A4CYP2D6 | |
| SCHEMBL16480073 | 0.66 | LMNA (0.49) | DPP7LMNACHRM2POLBRAB9A | |
| SCHEMBL24345978 | 0.65 | CD274 (0.53) | CD274PDCD1LG2 | |
| Hydrochloric Acid SCHEMBL6077029 | 0.65 | LMNA (0.74) | DPP7LMNACHRM2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997033-B1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-11-15 | — | — | EP | disclosed |