Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 7/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.51 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.51 |
| ▸ | BCHE | P06276 | 5/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19604917 | 0.93 | GNAO1 (0.58) | GNAO1GNAI3GNAI1KCNH2 | |
| SCHEMBL24356351 | 0.91 | GNAO1 (0.61) | GNAO1GNAI3GNAI1KCNH2 | |
| SCHEMBL19604919 | 0.91 | GNAO1 (0.61) | GNAO1GNAI3GNAI1KCNH2 | |
| SCHEMBL14519150 | 0.87 | DRD2 (0.41) | — | |
| SCHEMBL1615678 | 0.87 | GNAO1 (0.50) | GNAO1GNAI3GNAI1KCNH2 | |
| SCHEMBL26494066 | 0.82 | GNAO1 (0.44) | GNAO1GNAI3GNAI1 | |
| SCHEMBL23710775 | 0.82 | BCHE (0.45) | BCHE | |
| SCHEMBL14519151 | 0.80 | KMT2A (0.39) | — | |
| SCHEMBL13010704 | 0.79 | KDM4E (0.40) | — | |
| SCHEMBL4762635 | 0.78 | DRD2 (0.46) | GNAO1GNAI3GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197036-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |