Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2603219 | 0.92 | SLC18A3 (0.43) | KMT2APKMSLC18A3KDM1ALMNA | |
| SCHEMBL14519148 | 0.85 | ALDH1A1 (0.39) | KMT2APKMSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL14652141 | 0.85 | ALDH1A1 (0.39) | KMT2APKMSMN1; SMN2LMNAOPRM1 | |
| SCHEMBL14519150 | 0.85 | DRD2 (0.41) | SMN1; SMN2 | |
| SCHEMBL2116406 | 0.81 | GNAI3 (0.39) | SLC18A3 | |
| SCHEMBL10442555 | 0.81 | SLC18A3 (0.37) | KMT2APKMSLC18A3LMNAOPRM1 | |
| SCHEMBL12384497 | 0.81 | SLC18A3 (0.37) | KMT2APKMSLC18A3LMNAOPRM1 | |
| SCHEMBL6026443 | 0.80 | SLC18A3 (0.43) | KMT2APKMSLC18A3KDM1ALMNA | |
| SCHEMBL13010704 | 0.80 | KDM4E (0.40) | KMT2ASMN1; SMN2OPRM1OPRL1KDM4E | |
| SCHEMBL19602200 | 0.80 | GNAO1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |