Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MAOB | P27338 | 4/20 | 0.74 |
| ▸ | MAOA | P21397 | 2/20 | 0.74 |
| ▸ | ACHE | P22303 | 2/20 | 0.65 |
| ▸ | BACE1 | P56817 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.56 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424563 | 0.85 | MAOB (0.74) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL5424561 | 0.85 | MAOB (0.74) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL4362332 | 0.85 | CHRNA7 (0.82) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL7956659 | 0.85 | MAPT (0.74) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL2376112 | 0.85 | MAPT (0.74) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL28906335 | 0.84 | MAPT (0.72) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL2374997 | 0.82 | MAPT (0.70) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL10830261 | 0.82 | AR (0.78) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL2374989 | 0.82 | MAPT (0.70) | MAPTNPSR1L3MBTL1MAOBMAOA | |
| SCHEMBL5088006 | 0.82 | MAPT (0.76) | MAPTNPSR1L3MBTL1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407410-B2 | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication | VIIV Healthcare UK (No.5) Limited (GB) | 2019-09-10 | — | — | US | disclosed |
| US-10407410-B2 | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication | VIIV Healthcare UK (No.5) Limited (GB) | 2019-09-10 | — | — | US | disclosed |
| US-20190127351-A1 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY | 2019-05-02 | — | — | US | disclosed |
| US-20190127351-A1 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY | 2019-05-02 | — | — | US | disclosed |
| WO-2017195113-A1 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2017-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407410-B2 | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication | TYMP, TYMS, DUT | MAPT 1860/4885NPSR1 4790/4885L3MBTL1 3250/4885 |
| US-20190127351-A1 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | TYMP, TYMS, DUT | MAPT 1860/4885NPSR1 4790/4885L3MBTL1 3250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.