Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | GUSB | P08236 | 4/20 | 0.73 |
| ▸ | MAOB | P27338 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | CTSL | P07711 | 2/20 | 0.64 |
| ▸ | AR | P10275 | 1/20 | 0.64 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634059 | 0.90 | CHRNA7 (1.00) | CHRNA7MAPTNPSR1GUSBMAOB | |
| SCHEMBL634060 | 0.90 | CHRNA7 (1.00) | CHRNA7MAPTNPSR1GUSBMAOB | |
| SCHEMBL25195306 | 0.88 | CYP3A4 (0.82) | CHRNA7MAPTNPSR1MAOBMAOA | |
| SCHEMBL23303982 | 0.88 | CYP3A4 (0.82) | CHRNA7MAPTNPSR1MAOBMAOA | |
| SCHEMBL19603333 | 0.85 | MAPT (1.00) | CHRNA7MAPTNPSR1L3MBTL1MAOB | |
| SCHEMBL10830261 | 0.85 | AR (0.78) | MAPTNPSR1L3MBTL1GUSBMAOB | |
| SCHEMBL31619687 | 0.84 | CHRNA7 (0.82) | CHRNA7MAPTNPSR1GUSBMAOB | |
| SCHEMBL5512150 | 0.84 | CHRNA7 (0.81) | CHRNA7MAPTNPSR1GUSBMAOB | |
| SCHEMBL127853 | 0.84 | GUSB (1.00) | CHRNA7MAPTGUSBMAOBMAOA | |
| SCHEMBL4969800 | 0.84 | CHRNA7 (0.81) | CHRNA7MAPTNPSR1GUSBMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482340-B2 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2009-01-27 | — | — | US | disclosed |
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2006-10-26 | — | — | US | disclosed |
| EP-1583759-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063191-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | SLC8B1, CACNA1A, MCU | CHRNA7 1325/4885MAPT 2223/4885NPSR1 945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.