Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27870881 | 0.86 | HCRTR2 (0.42) | KDM4CALOX5APFEN1HCRTR2HCRTR1 | |
| SCHEMBL30227102 | 0.85 | KDM4C (0.48) | KDM4CHCRTR2HCRTR1CYP3A4KDM4E | |
| SCHEMBL30776208 | 0.85 | KDM4C (0.48) | KDM4CHCRTR2HCRTR1CYP3A4KDM4E | |
| SCHEMBL28532968 | 0.85 | KDM4C (0.48) | KDM4CHCRTR2HCRTR1CYP3A4KDM4E | |
| SCHEMBL30776205 | 0.85 | KDM4C (0.48) | KDM4CHCRTR2HCRTR1CYP3A4KDM4E | |
| SCHEMBL15459585 | 0.85 | SIRT3 (0.43) | KDM4CCYP17A1HCRTR2HCRTR1POLB | |
| SCHEMBL19599255 | 0.84 | HCRTR2 (0.44) | KDM4CHCRTR2HCRTR1POLBCYP3A4 | |
| SCHEMBL45147 | 0.83 | BCAT2 (0.53) | KDM4CALOX5APFEN1HCRTR2HCRTR1 | |
| SCHEMBL31227852 | 0.83 | BCAT2 (0.53) | KDM4CALOX5APFEN1HCRTR2HCRTR1 | |
| SCHEMBL30521876 | 0.83 | BCAT2 (0.53) | KDM4CALOX5APFEN1HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327490-A1 | PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327490-A1 | PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | KDM4C 2077/4885ALOX5AP 1552/4885FEN1 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.