Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651852 | 0.78 | POLB (0.41) | — | |
| SCHEMBL17079438 | 0.78 | KDM4C (0.33) | — | |
| SCHEMBL15645770 | 0.74 | MALT1 (0.37) | — | |
| SCHEMBL4660326 | 0.74 | MAPK9 (0.39) | MAPK9MAPK10 | |
| SCHEMBL20746229 | 0.72 | ALDH1A1 (0.40) | — | |
| SCHEMBL10351096 | 0.72 | L3MBTL1 (0.40) | — | |
| SCHEMBL26664553 | 0.72 | L3MBTL1 (0.40) | — | |
| SCHEMBL1854514 | 0.70 | KMO (0.30) | — | |
| SCHEMBL21495102 | 0.70 | UHRF1 (0.42) | — | |
| SCHEMBL1555509 | 0.70 | TRPV1 (0.34) | MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363416-A1 | MK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-05-08 | — | — | EP | disclosed |
| WO-2023278759-A1 | MK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2014062938-A1 | RORY MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-04-24 | — | — | WO | disclosed |
| EP-2686317-A2 | RAF KINASE INHIBITORS | Selexagen Therapeutics, Inc. (US) | 2014-01-22 | — | — | EP | disclosed |
| EP-2513111-A1 | MK2 INHIBITORS | MSD Oss B.V. (NL) | 2012-10-24 | — | — | EP | disclosed |
| WO-2012125981-A2 | RAF KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2012-09-20 | — | — | WO | disclosed |
| WO-2011073119-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2011-06-23 | — | — | WO | disclosed |