Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12964388 | 0.93 | HRH4 (0.48) | CA12CA1CA2CA9ACHE | |
| SCHEMBL20075911 | 0.88 | CA12 (0.49) | CA12CA1CA2CA9ACHE | |
| SCHEMBL24295090 | 0.85 | ACACB (0.42) | CA12CA1CA2CA9ACHE | |
| SCHEMBL30423191 | 0.84 | ADRB1 (0.50) | ACHEACACBHRH4 | |
| SCHEMBL18551071 | 0.84 | CA12 (0.48) | CA12CA1CA2CA9ACHE | |
| SCHEMBL28019839 | 0.81 | OGA (0.51) | CA12CA1CA2CA9ACHE | |
| SCHEMBL30230144 | 0.81 | OGA (0.51) | CA12CA1CA2CA9ACHE | |
| SCHEMBL18551580 | 0.81 | NUDT1 (0.51) | CA12CA1CA2CA9ACHE | |
| SCHEMBL23867275 | 0.81 | HRH4 (0.50) | CA12CA1CA2CA9ACHE | |
| SCHEMBL1275993 | 0.79 | ACHE (0.60) | CA12CA1CA2CA9ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197055-A1 | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |
| WO-2017197051-A1 | AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |