Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 5/20 | 0.47 |
| ▸ | PNMT | P11086 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836981 | 1.00 | HSP90AA1 (0.50) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| SCHEMBL22615041 | 1.00 | HSP90AA1 (0.50) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| Hydrochloric Acid SCHEMBL11553545 | 0.98 | HSP90AA1 (0.49) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| SCHEMBL13012444 | 0.84 | HSD17B10 (0.39) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| SCHEMBL2130637 | 0.84 | HSP90AA1 (0.44) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| SCHEMBL2130632 | 0.84 | HSP90AA1 (0.44) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| SCHEMBL18703985 | 0.81 | TAAR1 (0.53) | TAAR1IDO1PNMTIGF1RALOX15 | |
| SCHEMBL18703983 | 0.81 | TAAR1 (0.53) | TAAR1IDO1PNMTIGF1RALOX15 | |
| SCHEMBL9314304 | 0.81 | TAAR1 (0.63) | HSP90AA1POLBLMNAKMT2ATAAR1 | |
| SCHEMBL14827527 | 0.78 | CTBP2 (0.53) | HSP90AA1LMNAKMT2ATAAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215505-B1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | Bayer Pharma AG (DE) | 2019-07-24 | — | — | EP | disclosed |
| US-10118930-B2 | Piperidinylpyrazolopyrimidinones and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-06 | — | — | US | disclosed |
| US-20170334917-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10118930-B2 | Piperidinylpyrazolopyrimidinones and their use | HAMP, SERPINC1, PRSS8 | HSP90AA1 58/4885POLB 3149/4885LMNA 2585/4885 |
| US-20170334917-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | HAMP, SERPINC1, PRSS8 | HSP90AA1 58/4885POLB 3149/4885LMNA 2585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.