⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25328102 | 0.92 | TDP1 (0.33) | — | |
| SCHEMBL27856421 | 0.82 | TDP1 (0.39) | — | |
| SCHEMBL28824126 | 0.78 | EPHX1 (0.46) | — | |
| Ammonia Solution, Strong SCHEMBL28111373 | 0.77 | EPHX1 (0.44) | — | |
| SCHEMBL28184077 | 0.77 | PAOX (0.46) | — | |
| SCHEMBL28132626 | 0.77 | GRM4 (0.31) | — | |
| SCHEMBL29285179 | 0.77 | TDP1 (0.36) | — | |
| SCHEMBL14378864 | 0.77 | PAOX (0.46) | — | |
| SCHEMBL28251787 | 0.77 | KISS1R (0.36) | — | |
| SCHEMBL27541532 | 0.77 | CNR2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562917-B2 | Chimeric compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| CN-110520413-A | Big ring broad-spectrum antibiotic | RQX PHARMACEUTICALS INC | 2019-11-29 | — | — | CN | disclosed |
| US-20190276474-A1 | CHIMERIC COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. | 2019-09-12 | — | — | US | disclosed |
| US-10144745-B2 | Chimeric compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2018-12-04 | — | — | US | disclosed |
| CN-108368040-A | Diaryl monocyclic β -lactam compounds and methods of use thereof for treating bacterial infections | 默沙东公司 | 2018-08-03 | — | — | CN | disclosed |
| US-9938302-B2 | Chimeric compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2018-04-10 | — | — | US | disclosed |
| US-20170333443-A1 | CHIMERIC COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. | 2017-11-23 | — | — | US | disclosed |
| US-20170334932-A1 | CHIMERIC COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. | 2017-11-23 | — | — | US | disclosed |
| WO-2017201069-A1 | OXOINDOLINE DERIVATIVES AS PROTEIN FUNCTION MODULATORS | BIOTHERYX, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| CN-107108569-A | Antibacterial compounds with broad spectrum activity | 方济各安吉利克化学联合股份有限公司 | 2017-08-29 | — | — | CN | disclosed |