Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615641 | 0.93 | PLA2G4B (0.54) | NR4A2MEN1KMT2AMRGPRX4SRD5A2 | |
| SCHEMBL19615520 | 0.92 | NR4A2 (0.61) | NR4A2KMT2AMRGPRX4TSHRSMN1; SMN2 | |
| SCHEMBL19615694 | 0.89 | NR4A2 (0.57) | NR4A2MEN1KMT2AFFAR1MRGPRX4 | |
| SCHEMBL19615654 | 0.89 | AKR1C3 (0.49) | NR4A2SMN1; SMN2 | |
| SCHEMBL19631994 | 0.88 | KDM6B (0.51) | NR4A2PLA2G4B | |
| SCHEMBL19615487 | 0.86 | MRGPRX4 (0.51) | NR4A2MRGPRX4NR1H4 | |
| SCHEMBL19615728 | 0.86 | LMNA (0.52) | MEN1KMT2AMRGPRX4SMN1; SMN2 | |
| SCHEMBL19615691 | 0.85 | KDM5A (0.48) | NR4A2MEN1KMT2AFFAR1PLA2G4B | |
| SCHEMBL19632190 | 0.84 | NR4A2 (0.48) | NR4A2MEN1KMT2AMRGPRX4SMN1; SMN2 | |
| SCHEMBL19616024 | 0.84 | NR4A2 (0.51) | NR4A2MRGPRX4NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | claimed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |