Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.61 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | KDM5A | P29375 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615548 | 0.93 | NR4A2 (0.56) | NR4A2PPARAMAOBKDM5AKDM4C | |
| SCHEMBL19615441 | 0.92 | NR4A2 (0.57) | NR4A2MRGPRX4MAOBNR4A1NR4A3 | |
| SCHEMBL19615660 | 0.89 | NR4A2 (0.60) | NR4A2PPARAMRGPRX4MAOBKDM5A | |
| SCHEMBL19632190 | 0.87 | NR4A2 (0.48) | NR4A2MRGPRX4KDM5AKDM4CKDM5B | |
| SCHEMBL19631870 | 0.86 | KDM4C (0.48) | NR4A2PPARAKDM5AKDM4CKDM5B | |
| SCHEMBL19615641 | 0.85 | PLA2G4B (0.54) | NR4A2MRGPRX4MAOBKDM5AKDM4C | |
| SCHEMBL19616535 | 0.84 | NR4A2 (0.56) | NR4A2PPARAMAOBKDM5AKDM4C | |
| SCHEMBL19615728 | 0.83 | LMNA (0.52) | MRGPRX4KDM5AKDM4CKDM5BSMN1; SMN2 | |
| SCHEMBL19615654 | 0.83 | AKR1C3 (0.49) | NR4A2KDM5AKDM4CKDM5BSMN1; SMN2 | |
| SCHEMBL19631994 | 0.82 | KDM6B (0.51) | NR4A2KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | claimed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |