Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.54 |
| ▸ | KDM6B | O15054 | 2/20 | 0.54 |
| ▸ | KDM5C | P41229 | 2/20 | 0.54 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.54 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.45 |
| ▸ | KDM5A | P29375 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144228 | 0.86 | KDM4E (0.53) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL70350 | 0.84 | KDM4E (0.62) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL30065796 | 0.84 | KDM4E (0.62) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL19631878 | 0.84 | KDM4E (0.51) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL17145139 | 0.83 | SMN1; SMN2 (0.53) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL19615962 | 0.82 | KDM4E (0.52) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL475565 | 0.81 | KDM4E (0.68) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL30779113 | 0.81 | KDM4E (0.68) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL30378954 | 0.81 | KDM4E (0.58) | KDM4EKDM4CKDM6BKDM5CKDM2A | |
| SCHEMBL1759313 | 0.81 | KDM4E (0.58) | KDM4EKDM4CKDM6BKDM5CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |