Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738958 | 0.98 | LMNA (0.50) | LMNATSHRTP53CYP3A4MAPK1 | |
| SCHEMBL8863229 | 0.98 | LMNA (0.50) | LMNATSHRTP53CYP3A4MAPK1 | |
| SCHEMBL2421526 | 0.95 | LMNA (0.54) | LMNATSHRTP53CYP3A4MAPK1 | |
| SCHEMBL20267553 | 0.89 | ALDH1A1 (0.44) | LMNATSHRCYP3A4ALDH1A1ESR1 | |
| SCHEMBL564394 | 0.84 | NPC1 (0.38) | LMNATSHRALDH1A1MMP2MMP9 | |
| SCHEMBL29045186 | 0.83 | NPC1 (0.38) | LMNAALDH1A1MMP2MMP9MMP12 | |
| SCHEMBL152733 | 0.82 | NUDT1 (0.49) | LMNATSHRCYP3A4MAPK1ALDH1A1 | |
| SCHEMBL27964293 | 0.81 | NUDT1 (0.39) | LMNACYP3A4MAPK1ALDH1A1NPC1 | |
| SCHEMBL28419847 | 0.81 | TSHR (0.46) | LMNATSHRALDH1A1NPC1RAB9A | |
| SCHEMBL9797904 | 0.81 | TSHR (0.50) | LMNATSHRTP53CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011067588-A1 | CYCLIC SULPHINYL ESTERS OF CYTIDINE | GENERICS [UK] LIMITED (GB) | 2011-06-09 | — | — | WO | claimed |
| WO-2011104540-A1 | ONE STEP PROCESS FOR THE PREPARATION OF CAPECITABINE | GENERICS [UK] LIMITED (GB) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011067588-A1 | CYCLIC SULPHINYL ESTERS OF CYTIDINE | GENERICS [UK] LIMITED (GB) | 2011-06-09 | — | — | WO | disclosed |
| CN-1022832-C | Preparation of 3-substituted-2-oxindole derivatives | PFIZER (US) | 1993-11-24 | — | — | CN | disclosed |
| CN-1046525-A | 3-SUBSTITUTED-2-OXINDOLE DERIVATIVES | PFIZER (US) | 1990-10-31 | — | — | CN | disclosed |