Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PRNP | P04156 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18254476 | 0.78 | QPCT (0.33) | PNPMEN1KMT2AHTTNAMPT | |
| SCHEMBL9222064 | 0.74 | PNP (0.40) | PNPMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL7093036 | 0.72 | PNP (0.46) | PNPMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL18710632 | 0.72 | PNP (0.39) | PNPMEN1KMT2A | |
| SCHEMBL7031302 | 0.72 | ADRA2A (0.46) | — | |
| SCHEMBL24355260 | 0.69 | CTSS (0.39) | PNPMEN1KMT2APTGESMAPT | |
| SCHEMBL27472961 | 0.69 | CTNNB1 (0.38) | PNPMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL17036636 | 0.68 | ADRA2A (0.54) | HTTNAMPTEPHX1MAPT | |
| SCHEMBL19619685 | 0.68 | ALDH1A1 (0.38) | KMT2AHTTSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL763087 | 0.65 | PARP1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822107-B2 | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-21 | — | — | US | disclosed |