Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CCR8 | P51685 | 1/20 | 0.61 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15564843 | 0.89 | KDM4E (0.65) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL7302723 | 0.85 | CCR8 (0.70) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL15565341 | 0.83 | ENPP2 (0.81) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL20953370 | 0.83 | ENPP2 (0.81) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL15565343 | 0.83 | ENPP2 (0.81) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL15564373 | 0.82 | ENPP2 (0.83) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL15564750 | 0.82 | ENPP2 (0.83) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL15564416 | 0.82 | ENPP2 (0.56) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL15565705 | 0.82 | ENPP2 (0.83) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 | |
| SCHEMBL20404066 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTSMN1; SMN2CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2879674-B1 | COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS | BIOGEN MA INC (US) | 2017-11-22 | — | — | EP | disclosed |