Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ADK | P55263 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620490 | 0.95 | ADK (0.38) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL19620603 | 0.91 | POLB (0.50) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL19620342 | 0.90 | MDM2 (0.36) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL19620548 | 0.90 | MEN1 (0.40) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL19620609 | 0.90 | MDM2 (0.38) | KDM4EPOLBMAPTADKRAB9A | |
| SCHEMBL19620505 | 0.90 | LMNA (0.37) | KDM4EPOLBMAPTKMT2AMEN1 | |
| SCHEMBL19620689 | 0.89 | KDM4E (0.38) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL19620675 | 0.88 | MAPT (0.42) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL19620542 | 0.88 | POLB (0.42) | KDM4EPOLBMAPTKMT2AMEN1 | |
| SCHEMBL19620642 | 0.88 | ADK (0.38) | KDM4EPOLBMAPTADKMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |