Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.51 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.48 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594957 | 0.82 | EZH2 (0.69) | EZH2EZH1EEDSUZ12 | |
| SCHEMBL19610155 | 0.82 | EZH2 (0.54) | EZH2EZH1EEDSUZ12 | |
| SCHEMBL19570148 | 0.78 | EZH2 (0.70) | EZH2EZH1EEDSUZ12 | |
| SCHEMBL19620930 | 0.73 | EZH2 (0.51) | EZH2EZH1 | |
| SCHEMBL19620789 | 0.72 | EZH2 (0.50) | EZH2EEDSUZ12 | |
| SCHEMBL19620910 | 0.71 | EZH2 (0.64) | EZH2EZH1EEDSUZ12 | |
| SCHEMBL19570140 | 0.71 | EZH2 (0.69) | EZH2EZH1EEDSUZ12 | |
| SCHEMBL24090384 | 0.71 | EZH2 (0.71) | EZH2EEDSUZ12 | |
| SCHEMBL19620961 | 0.70 | EZH2 (0.66) | EZH2EZH1EEDSUZ12 | |
| SCHEMBL19621001 | 0.70 | EZH2 (0.63) | EZH2EZH1EEDSUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |