Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.36 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.36 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 10/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.34 |
| ▸ | EED | O75530 | 5/20 | 0.33 |
| ▸ | RBBP4 | Q09028 | 5/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.33 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.33 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20334459 | 0.79 | EZH2 (0.43) | KDM4EEZH2EEDRBBP4SUZ12 | |
| SCHEMBL1694607 | 0.77 | YTHDF2 (0.41) | KDM4EALDH1A1GLAPOLBGAA | |
| Hydrochloric Acid SCHEMBL1694726 | 0.76 | YTHDF2 (0.40) | KDM4EALDH1A1GLAPOLBGAA | |
| SCHEMBL17970490 | 0.74 | EZH2 (0.35) | KDM4EALDH1A1GLAPOLBGAA | |
| SCHEMBL9887551 | 0.73 | EZH2 (0.45) | GAAEZH2EEDRBBP4SUZ12 | |
| SCHEMBL14727105 | 0.73 | DAO (0.39) | KDM4EALDH1A1GLAPOLBGAA | |
| SCHEMBL2587816 | 0.72 | DAO (0.38) | KDM4EALDH1A1GLAPOLBGAA | |
| SCHEMBL1694956 | 0.71 | KDM4E (0.61) | KDM4EALDH1A1GLAPOLBGAA | |
| Hydrochloric Acid SCHEMBL2595212 | 0.71 | DAO (0.37) | KDM4EALDH1A1GLAPOLBGAA | |
| SCHEMBL5543692 | 0.70 | ADH1B (0.39) | ALDH1A1HSD17B10RAPGEF4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |