Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14924426 | 0.90 | MAPT (0.55) | MAPTSMN1; SMN2ALDH1A1GAASIGMAR1 | |
| SCHEMBL8245727 | 0.87 | USP2 (0.56) | MAPTSMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL3576656 | 0.85 | LMNA (0.51) | MAPTRAB9AKMT2AALDH1A1SRC | |
| SCHEMBL11096321 | 0.85 | SIGMAR1 (0.56) | MAPTRAB9AKMT2AALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4809788 | 0.84 | LMNA (0.50) | MAPTRAB9AKMT2AALDH1A1SRC | |
| SCHEMBL14262613 | 0.81 | KMT2A (0.43) | MAPTRAB9AKMT2AALDH1A1BACE1 | |
| SCHEMBL8276884 | 0.81 | FABP6 (0.43) | MAPTSMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL5929366 | 0.79 | SRC (0.45) | RAB9AKMT2AALDH1A1SRCGAA | |
| SCHEMBL2378167 | 0.79 | KMT2A (0.70) | MAPTSMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL13102339 | 0.77 | MAPT (0.57) | MAPTMBTD1L3MBTL1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |