Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.42 |
| ▸ | USP7 | Q93009 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623572 | 0.87 | PIK3CA (0.49) | PIK3CAMEN1KMT2AMTORPIK3CG | |
| SCHEMBL19623865 | 0.85 | PIK3CA (0.50) | PIK3CAMEN1KMT2AMTORPIK3CG | |
| SCHEMBL19623703 | 0.85 | PIK3CA (0.49) | PIK3CAMEN1KMT2AMTORPIK3CG | |
| SCHEMBL3833880 | 0.82 | PIK3CA (0.75) | PIK3CA | |
| SCHEMBL19623871 | 0.82 | PIK3CA (0.47) | PIK3CAMTORMAPTKDM4EHPGD | |
| SCHEMBL2378551 | 0.81 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL19623874 | 0.80 | MEN1 (0.48) | PIK3CAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL24697994 | 0.80 | PIK3CA (0.45) | PIK3CASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL24698899 | 0.79 | PRKD1 (0.42) | PIK3CATP53SMN1; SMN2MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL2378881 | 0.78 | PIK3CA (0.68) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |