Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NAPEPLD | Q6IQ20 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623703 | 0.84 | PIK3CA (0.49) | MEN1KMT2APIK3CAALDH1A1MTOR | |
| SCHEMBL19623865 | 0.83 | PIK3CA (0.50) | MEN1KMT2APIK3CAPDGFRBKDR | |
| SCHEMBL19623572 | 0.82 | PIK3CA (0.49) | MEN1KMT2APIK3CAMTOR | |
| SCHEMBL2378244 | 0.81 | PIK3CA (0.64) | PIK3CAPDGFRBKDR | |
| SCHEMBL19623601 | 0.80 | PIK3CA (0.49) | MEN1KMT2APIK3CAHTTSMN1; SMN2 | |
| SCHEMBL24698899 | 0.78 | PRKD1 (0.42) | MEN1KMT2APIK3CASMN1; SMN2MTOR | |
| SCHEMBL19623871 | 0.78 | PIK3CA (0.47) | PIK3CAKDRHDAC6ALDH1A1MTOR | |
| SCHEMBL24697994 | 0.78 | PIK3CA (0.45) | MEN1KMT2APIK3CASMN1; SMN2 | |
| SCHEMBL24697633 | 0.78 | PIK3CA (0.41) | MEN1KMT2APIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL19623886 | 0.77 | PIK3CA (0.49) | MEN1KMT2APIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |