Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 3/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | TEC | P42680 | 1/20 | 0.30 |
| ▸ | TXK | P42681 | 1/20 | 0.30 |
| ▸ | BMX | P51813 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | CD69 | Q07108 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19544642 | 0.81 | SYK (0.47) | BTKMKNK1MKNK2SYKEGFR | |
| SCHEMBL19533518 | 0.69 | MKNK1 (0.49) | MKNK1MKNK2SCN9A | |
| SCHEMBL21108890 | 0.64 | BTK (0.60) | BTKSYKEGFRJAK2LYN | |
| SCHEMBL19544867 | 0.64 | SYK (0.48) | BTKSYKEGFRJAK2LYN | |
| SCHEMBL27631855 | 0.62 | DHFR (0.40) | SYKDHFR | |
| SCHEMBL304096 | 0.62 | XDH (0.53) | MKNK1MKNK2ADORA2AADORA1MAPK14 | |
| SCHEMBL30491699 | 0.62 | XDH (0.53) | MKNK1MKNK2ADORA2AADORA1MAPK14 | |
| SCHEMBL3349561 | 0.60 | MPO (0.39) | MKNK1MKNK2SCN9A | |
| SCHEMBL303982 | 0.59 | CYP17A1 (0.56) | MKNK1MKNK2MAPK14 | |
| SCHEMBL4572945 | 0.57 | MKNK1 (0.47) | MKNK1MKNK2SCN9AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246317-A1 | BTK INHIBITOR | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. (CN) | 2017-11-22 | — | — | EP | disclosed |