Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | EDNRA | P25101 | 5/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940868 | 1.00 | NPC1 (0.58) | NPC1ALDH1A1TP53MAPTTSHR | |
| SCHEMBL7439246 | 1.00 | NPC1 (0.58) | NPC1ALDH1A1TP53MAPTTSHR | |
| SCHEMBL7429787 | 1.00 | NPC1 (0.58) | NPC1ALDH1A1TP53MAPTTSHR | |
| SCHEMBL9501146 | 0.92 | NPC1 (0.56) | NPC1ALDH1A1TP53MAPTTSHR | |
| SCHEMBL11047694 | 0.86 | CTSL (0.43) | NPC1ALDH1A1TP53MAPTTSHR | |
| SCHEMBL19614362 | 0.83 | RAB9A (0.55) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19614361 | 0.83 | RAB9A (0.55) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL10941996 | 0.82 | CTSL (0.41) | ALDH1A1TSHRATMSMN1; SMN2CYP3A4 | |
| SCHEMBL10938858 | 0.82 | CTSL (0.41) | ALDH1A1TSHRATMSMN1; SMN2CYP3A4 | |
| SCHEMBL10941915 | 0.82 | CTSL (0.41) | ALDH1A1TSHRATMSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920342-B2 | Process for the preparation of Droxidopa | DIVI'S LABORATORIES LIMITED | 2018-03-20 | — | — | US | disclosed |
| US-9920342-B2 | Process for the preparation of Droxidopa | DIVI'S LABORATORIES LIMITED | 2018-03-20 | — | — | US | disclosed |
| US-20170335357-A1 | PROCESS FOR THE PREPARATION OF DROXIDOPA | DIVI'S LABORATORIES LIMITED (IN) | 2017-11-23 | — | — | US | disclosed |
| US-20170335357-A1 | PROCESS FOR THE PREPARATION OF DROXIDOPA | DIVI'S LABORATORIES LIMITED (IN) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170335357-A1 | PROCESS FOR THE PREPARATION OF DROXIDOPA | DAO, DDO, DNPEP | NPC1 3148/4885ALDH1A1 1112/4885TP53 4005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.