Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 3/20 | 0.66 |
| ▸ | APAF1 | O14727 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296978 | 0.92 | APAF1 (0.63) | MITFAPAF1MAPTCHRM1ALDH1A1 | |
| SCHEMBL16296699 | 0.90 | APAF1 (0.66) | MITFAPAF1MAPTCHRM1ALDH1A1 | |
| SCHEMBL19625602 | 0.87 | APAF1 (0.57) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL19625603 | 0.86 | APAF1 (0.67) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL19625600 | 0.84 | MAPT (0.69) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL19625601 | 0.84 | APAF1 (0.52) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL24355094 | 0.82 | MITF (0.73) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL16297152 | 0.79 | APAF1 (0.60) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL16297161 | 0.77 | HSP90AA1 (0.55) | MITFAPAF1MAPTNPC1RAB9A | |
| SCHEMBL16296937 | 0.77 | APAF1 (0.53) | MITFAPAF1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334842-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334842-A1 | INHIBITORS OF THE MITF MOLECULAR PATHWAY | MITF, TFEB, TYR | MITF 1/4885APAF1 2521/4885MAPT 4092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.