Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196374 | 1.00 | EPHA2 (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL16910352 | 1.00 | EPHA2 (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL19881471 | 0.91 | HTR3A (0.34) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL10083541 | 0.89 | LMNA (0.34) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| Vosaroxin SCHEMBL15933161 | 0.89 | HTR3A (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| Vosaroxin SCHEMBL674441 | 0.89 | HTR3A (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| Vosaroxin SCHEMBL195037 | 0.89 | HTR3A (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| Vosaroxin SCHEMBL3207291 | 0.89 | HTR3A (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL15802906 | 0.89 | EPHA2 (0.36) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| Vosaroxin SCHEMBL7824869 | 0.88 | HTR3A (0.35) | EPHA2FLT4GSK3BRARBTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382214-A1 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-Ý(3S,4S)-3METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL¨-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID | Sunesis Pharmaceuticals, Inc. (US) | 2011-11-02 | — | — | EP | claimed |
| WO-2010078294-A1 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-[(3S,4S)-3METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID | SUNESIS PHARMACEUTICAL, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| EP-2400959-A1 | METHODS OF USING SNS-595 FOR TREATMENT OF CANCER SUBJECTS WITH REDUCED BRCA2 ACTIVITY | Sunesis Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2382214-A1 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-Ý(3S,4S)-3METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL¨-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID | Sunesis Pharmaceuticals, Inc. (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010099526-A1 | METHODS OF USING SNS-595 FOR TREATMENT OF CANCER SUBJECTS WITH REDUCED BRCA2 ACTIVITY | SUNESIS PHARMACEUTICALS, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010078294-A1 | METHOD OF PREPARING (+)-1,4-DIHYDRO-7-[(3S,4S)-3METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID | SUNESIS PHARMACEUTICAL, INC. (US) | 2010-07-08 | — | — | WO | disclosed |