Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19627011 | 0.91 | MAPT (0.54) | EGFRKDM4EMAPTSCN9AHTT | |
| SCHEMBL19625500 | 0.85 | KDM4E (0.43) | EGFRKDM4EMAPTHTTALDH1A1 | |
| SCHEMBL19626604 | 0.79 | HTT (0.53) | EGFRKDM4EMAPTSCN9AHTT | |
| SCHEMBL7080057 | 0.77 | SCN9A (0.52) | KDM4EMAPTSCN9AALDH1A1TSHR | |
| SCHEMBL19625371 | 0.77 | MAPT (0.51) | KDM4EMAPTHTTALDH1A1TDP1 | |
| SCHEMBL12647586 | 0.77 | MAPT (0.47) | KDM4EMAPTSCN9AALDH1A1ENPP1 | |
| SCHEMBL17626050 | 0.75 | ENPP1 (0.38) | KDM4EMAPTHTTALDH1A1ENPP1 | |
| SCHEMBL15473185 | 0.75 | PDE5A (0.49) | SCN9AHTTSREBF2CYP19A1 | |
| SCHEMBL19626757 | 0.75 | MEN1 (0.54) | EGFRKDM4EMAPTALDH1A1TDP1 | |
| SCHEMBL12968478 | 0.74 | ATP4A (0.51) | SCN9AHTTALDH1A1SREBF2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | EGFR 794/4885KDM4E 3779/4885MAPT 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.