Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MPL | P40238 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.37 |
| ▸ | ATP4B | P51164 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31311390 | 0.83 | MPL (0.71) | ALDH1A1MPLAPEX1PTPN1CDC25B | |
| SCHEMBL19625308 | 0.80 | MPL (0.49) | ALDH1A1HPGDMPLAPEX1PTGS2 | |
| SCHEMBL8188473 | 0.79 | ALDH1A1 (0.61) | ALDH1A1HPGDMPLAPEX1PTGS2 | |
| SCHEMBL21283241 | 0.79 | KDM1A (0.38) | MPLPTGS2PTGS1PTGDR2 | |
| SCHEMBL18997360 | 0.78 | MPL (0.44) | ALDH1A1MPLAPEX1PTPN1CDC25B | |
| SCHEMBL2093695 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDCYP1A2GAA | |
| SCHEMBL2090659 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HPGDAPEX1PTGS2PTGS1 | |
| SCHEMBL19626571 | 0.75 | ALDH1A1 (0.51) | ALDH1A1HPGDCD274PTGDR2IDO1 | |
| SCHEMBL8462970 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL327289 | 0.75 | JAK2 (0.51) | ALDH1A1PTGS2PTGS1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | ALDH1A1 1166/4885HPGD 1547/4885MPL 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.