Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19626610 | 0.89 | MPL (0.41) | MPLHCKNR2C2BTKCSF1R | |
| SCHEMBL19626597 | 0.87 | TRIM24 (0.48) | TRIM24CASP3CASP2MPLALDH1A1 | |
| SCHEMBL19626779 | 0.86 | ALDH1A1 (0.47) | TRIM24CASP3CASP2MPLALDH1A1 | |
| SCHEMBL19626780 | 0.84 | NOTUM (0.54) | TRIM24MPLALDH1A1MAPTGAA | |
| SCHEMBL17625970 | 0.82 | NOTUM (0.41) | HCKNR2C2BTKCSF1RNTRK1 | |
| SCHEMBL19625439 | 0.75 | MAPT (0.48) | TRIM24ALDH1A1MAPTGAAHPGD | |
| SCHEMBL19626792 | 0.75 | NOTUM (0.45) | MPLALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL17400548 | 0.75 | MPL (0.63) | MPLALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL19626793 | 0.73 | NOTUM (0.52) | MPLFLT3MAPTKDM4EHPGD | |
| SCHEMBL21301011 | 0.73 | AR (0.48) | MPLALDH1A1MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | TRIM24 3531/4885CASP3 2387/4885CASP2 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.