Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PDE8B | O95263 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13337023 | 0.83 | CXCR4 (0.41) | OPRM1OPRL1HTR2CCXCR4FNTA | |
| SCHEMBL16327619 | 0.82 | HTR2A (0.46) | OPRM1OPRL1ALDH1A1MAPK1HTR2C | |
| SCHEMBL25894886 | 0.79 | OPRM1 (0.46) | OPRM1OPRL1ALDH1A1MAPK1PDE8B | |
| SCHEMBL19046969 | 0.79 | OPRM1 (0.46) | OPRM1OPRL1ALDH1A1MAPK1PDE8B | |
| SCHEMBL25894888 | 0.79 | OPRM1 (0.46) | OPRM1OPRL1ALDH1A1MAPK1PDE8B | |
| SCHEMBL32676862 | 0.78 | OPRM1 (0.48) | OPRM1OPRL1ALDH1A1MAPK1HTR2C | |
| SCHEMBL30095938 | 0.78 | OPRM1 (0.48) | OPRM1OPRL1ALDH1A1MAPK1HTR2C | |
| SCHEMBL32676674 | 0.78 | OPRM1 (0.48) | OPRM1OPRL1ALDH1A1MAPK1HTR2C | |
| SCHEMBL20370041 | 0.78 | ALDH1A1 (0.36) | OPRM1OPRL1ALDH1A1MAPK1FNTA | |
| SCHEMBL32676904 | 0.77 | OPRM1 (0.44) | OPRM1OPRL1ALDH1A1MAPK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10358437-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10316023-B2 | — | — | 2019-06-11 | — | — | US | disclosed |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316023-B2 | — | PKD1, NHERF1, PCSK6 | OPRM1 2947/4885OPRL1 1255/4885ALDH1A1 1008/4885 |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | PKD1, NHERF1, HDAC10 | OPRM1 3220/4885OPRL1 1366/4885ALDH1A1 782/4885 |
| US-10358437-B2 | Therapeutic compounds and uses thereof | PKD1, NHERF1, HDAC10 | OPRM1 3220/4885OPRL1 1366/4885ALDH1A1 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.