Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19627137 | 0.89 | CYP1A2 (0.34) | KDM4ECYP3A4 | |
| SCHEMBL19627101 | 0.80 | TSHR (0.32) | KDM4ECYP3A4CYP2D6THPOTSHR | |
| SCHEMBL19627140 | 0.79 | KDM4E (0.31) | KDM4ECYP3A4CYP2D6THPOTSHR | |
| SCHEMBL19627102 | 0.75 | TRPA1 (0.31) | KDM4ETSHR | |
| SCHEMBL26323055 | 0.72 | KDM4E (0.31) | KDM4ETSHR | |
| SCHEMBL17793592 | 0.69 | SLC6A4 (0.41) | KDM4ECYP3A4CYP2D6THPO | |
| SCHEMBL26927609 | 0.68 | CYP3A4 (0.33) | CYP3A4CYP2D6THPO | |
| SCHEMBL26323053 | 0.67 | KDM4E (0.31) | KDM4ETSHR | |
| SCHEMBL19630692 | 0.67 | SLC6A4 (0.42) | KDM4ETSHR | |
| SCHEMBL19627105 | 0.67 | SLC6A4 (0.50) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840541-B2 | Opioid receptor modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-12-12 | — | — | US | disclosed |
| US-20230271976-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-31 | — | — | US | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | KDM4E 1197/4885CYP3A4 390/4885CYP2D6 480/4885 |
| US-20230271976-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | KDM4E 1372/4885CYP3A4 511/4885CYP2D6 631/4885 |
| US-11840541-B2 | Opioid receptor modulators | OPRM1, OPRL1, OPRD1 | KDM4E 1197/4885CYP3A4 390/4885CYP2D6 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.