Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | CASP3 | P42574 | 4/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19627239 | 0.91 | DYRK1A (0.60) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL17770431 | 0.86 | LRRK2 (0.71) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL19627279 | 0.85 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL19627212 | 0.85 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL13236116 | 0.84 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL17770342 | 0.84 | DHODH (0.76) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL17770408 | 0.83 | DYRK1A (0.61) | NPC1RAB9AKDM4ESMN1; SMN2NFKB1 | |
| SCHEMBL30472744 | 0.83 | CSNK1D (0.62) | MEN1KMT2ADYRK1ACSNK1DMAP4K5 | |
| SCHEMBL17770389 | 0.83 | CSNK1D (0.62) | MEN1KMT2ADYRK1ACSNK1DMAP4K5 | |
| SCHEMBL19627233 | 0.83 | MAPT (0.58) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334869-A1 | NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334869-A1 | NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER | AK2, PC, GLS2 | NPC1 684/4885RAB9A 4019/4885MEN1 3692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.