Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.57 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.57 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.53 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 3/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19627243 | 0.91 | NPC1 (0.63) | DYRK1ACASP3SENP7KDM4EMEN1 | |
| SCHEMBL19627224 | 0.85 | DYRK1A (0.58) | DYRK1APTPN7PTPN12PTPN22DHODH | |
| SCHEMBL17770342 | 0.84 | DHODH (0.76) | DHODHTMPRSS4KCNMA1CASP3SENP7 | |
| SCHEMBL18418449 | 0.84 | DYRK1A (0.62) | DYRK1APTPN7PTPN12PTPN22CASP3 | |
| SCHEMBL19612136 | 0.83 | DYRK1A (0.61) | DYRK1ADHODHP2RX1TMPRSS4KCNMA1 | |
| SCHEMBL3617783 | 0.82 | DHODH (0.65) | DHODHKCNMA1CASP3SENP7KDM4E | |
| SCHEMBL19194695 | 0.82 | SCD (0.66) | DYRK1ADHODHCASP3SENP7MEN1 | |
| SCHEMBL19627233 | 0.81 | MAPT (0.58) | P2RX1TMPRSS4KCNMA1KDM4EMEN1 | |
| SCHEMBL15916250 | 0.79 | RAB9A (0.67) | P2RX1TMPRSS4KCNMA1MEN1NPC1 | |
| SCHEMBL19627241 | 0.79 | KCNMA1 (0.52) | DHODHP2RX1TMPRSS4KCNMA1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334869-A1 | NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334869-A1 | NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER | AK2, PC, GLS2 | DYRK1A 4289/4885PTPN7 1525/4885PTPN12 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.