Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 10/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CD63 | P08962 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616357 | 0.80 | L3MBTL1 (0.33) | L3MBTL1NUDT1SYK | |
| SCHEMBL31244474 | 0.75 | KDM4E (0.42) | L3MBTL1SYK | |
| SCHEMBL31244547 | 0.75 | L3MBTL1 (0.37) | L3MBTL1TNKSSYK | |
| SCHEMBL17318003 | 0.75 | AURKA (0.40) | SYKPARP1CD63 | |
| SCHEMBL17324666 | 0.75 | L3MBTL1 (0.30) | L3MBTL1 | |
| SCHEMBL19630404 | 0.74 | NUDT1 (0.45) | L3MBTL1NUDT1TNKSSYKCD63 | |
| SCHEMBL15687846 | 0.73 | L3MBTL1 (0.47) | L3MBTL1NUDT1TNKSSYK | |
| SCHEMBL22732873 | 0.73 | L3MBTL1 (0.32) | L3MBTL1SYK | |
| SCHEMBL31244472 | 0.73 | KDM4E (0.59) | — | |
| SCHEMBL24714425 | 0.71 | L3MBTL1 (0.33) | L3MBTL1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017200825-A1 | FUSED PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE STIMULATORS | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | WO | disclosed |