Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20696692 | 0.87 | ADRA1A (0.36) | TSHRHSD17B10ALDH1A1KMT2AKDM4E | |
| SCHEMBL18607000 | 0.87 | S1PR1 (0.36) | TSHRHSD17B10ALDH1A1KDM4ES1PR1 | |
| SCHEMBL19629880 | 0.85 | ALDH1A1 (0.45) | TSHRHSD17B10ALDH1A1CA1CA2 | |
| SCHEMBL21081632 | 0.85 | NPC1 (0.41) | TSHRLMNAHSD17B10ALDH1A1CA1 | |
| SCHEMBL1788945 | 0.82 | TSHR (0.50) | TSHRLMNAHSD17B10ALDH1A1CFTR | |
| SCHEMBL18617746 | 0.79 | LMNA (0.45) | TSHRLMNAHSD17B10ALDH1A1CFTR | |
| SCHEMBL277622 | 0.77 | KDM4E (0.45) | TSHRLMNAHSD17B10ALDH1A1CFTR | |
| SCHEMBL23058134 | 0.76 | TSHR (0.47) | TSHRLMNAHSD17B10ALDH1A1CFTR | |
| SCHEMBL1788233 | 0.74 | TSHR (0.57) | TSHRLMNAHSD17B10ALDH1A1CFTR | |
| Ammonia Solution, Strong SCHEMBL28371090 | 0.73 | TSHR (0.55) | TSHRLMNAHSD17B10ALDH1A1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198647-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-11-23 | — | — | WO | disclosed |