SCHEMBL19630018

SCHEMBL19630018

Cn1ccc2ncc(F)c(Cl)c21

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDR P35968 5/20 0.33
RPS6KA5 O75582 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
IRAK4 Q9NWZ3 1/20 0.31
EIF4E P06730 2/20 0.31
MKNK1 Q9BUB5 2/20 0.31
MKNK2 Q9HBH9 2/20 0.31
F2RL1 P55085 2/20 0.31
EGFR P00533 3/20 0.31
ERBB2 P04626 3/20 0.31
ERBB3 P21860 3/20 0.31
ERBB4 Q15303 3/20 0.31
BRD9 Q9H8M2 1/20 0.30
DPP4 P27487 1/20 0.30
APP P05067 1/20 0.30
BRAF P15056 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19630014 0.76 LMNA (0.35) SMN1; SMN2IRAK4EIF4EMKNK1MKNK2
SCHEMBL2598455 0.73 TUBB4A (0.35) SMN1; SMN2F2RL1BRD9
SCHEMBL21187465 0.73 DPP4 (0.45) DPP4BRAF
SCHEMBL30592408 0.71 F2RL1 (0.36) SMN1; SMN2F2RL1
SCHEMBL27404280 0.68 CCR1 (0.38) KDRIRAK4BRD9
SCHEMBL30051491 0.68 KDR (0.44) KDRIRAK4MKNK1MKNK2EGFR
SCHEMBL30667305 0.68 KDR (0.35) KDRRPS6KA5IRAK4EGFRERBB2
SCHEMBL130754 0.68 KDR (0.44) KDRIRAK4MKNK1MKNK2EGFR
SCHEMBL12608278 0.68 KDR (0.35) KDRRPS6KA5IRAK4EGFRERBB2
SCHEMBL2598395 0.66 TGFBR1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3458452-B1 HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION BUGWORKS RES INC (US) 2023-08-30 EP disclosed
EP-3458452-B1 HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION BUGWORKS RES INC (US) 2023-08-30 EP disclosed
US-10711011-B2 Substituted oxazolidines as anti-bacterial agents Bugworks Research, Inc. (US) 2020-07-14 US disclosed
US-20190292199-A1 HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION Bugworks Research, Inc. 2019-09-26 US disclosed
WO-2017199265-A1 HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION BUGWORKS RESEARCH INDIA PVT LTD (IN) 2017-11-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190292199-A1 HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION ALPI, UROD, HLA-C KDR 4812/4885RPS6KA5 2323/4885SMN1; SMN2 4211/4885
US-10711011-B2 Substituted oxazolidines as anti-bacterial agents ALPI, HLA-A, HLA-B KDR 4410/4885RPS6KA5 2050/4885SMN1; SMN2 3099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.