⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19700906 | 0.76 | PI4KA (0.35) | — | |
| SCHEMBL6832144 | 0.70 | CYP19A1 (0.35) | — | |
| SCHEMBL9841089 | 0.68 | FDPS (0.46) | — | |
| SCHEMBL21099139 | 0.64 | CYP19A1 (0.32) | — | |
| SCHEMBL21652238 | 0.64 | ALDH1A1 (0.33) | — | |
| SCHEMBL25854022 | 0.64 | NPC1 (0.43) | — | |
| SCHEMBL24497101 | 0.63 | — | — | |
| SCHEMBL20931179 | 0.62 | — | — | |
| SCHEMBL9944600 | 0.62 | ALDH1A1 (0.30) | — | |
| SCHEMBL14420986 | 0.60 | RORC (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3599236-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2023-08-23 | — | — | EP | disclosed |
| US-20200231567-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION | 2020-07-23 | — | — | US | disclosed |
| US-9828361-B2 | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORPORATION (US) | 2017-11-28 | — | — | US | disclosed |