Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP12 | P39900 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 3/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30131126 | 1.00 | MEN1 (0.49) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL3363106 | 0.86 | MEN1 (0.48) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL29302 | 0.85 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL31069910 | 0.85 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL8607117 | 0.85 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL10707097 | 0.85 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL19668120 | 0.85 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL29372521 | 0.85 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL23275566 | 0.83 | MMP9 (0.53) | MEN1KMT2ANPC1RAB9AMMP9 | |
| SCHEMBL3361977 | 0.83 | MEN1 (0.55) | MEN1KMT2ANPC1RAB9AMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11534427-B2 | Applications of novel thiazole derivative in treating inflammatory bowel diseases | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2022-12-27 | — | — | US | disclosed |
| EP-3459937-B1 | THIAZOLE DERIVATIVE AND APPLICATIONS | UNIV EAST CHINA SCIENCE & TECH (CN) | 2021-12-29 | — | — | EP | disclosed |
| US-10919869-B2 | Thiazole derivative and applications | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-02-16 | — | — | US | disclosed |
| US-20190290620-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING INFLAMMATORY BOWEL DISEASES | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-09-26 | — | — | US | disclosed |
| US-20190292162-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-09-26 | — | — | US | disclosed |
| EP-3459937-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | East China University of Science and Technology (CN) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198179-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING INFLAMMATORY BOWEL DISEASES | 华东理工大学 | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198178-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | 华东理工大学 | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11534427-B2 | Applications of novel thiazole derivative in treating inflammatory bowel diseases | FABP2, SLC10A2, ALPI | MEN1 4844/4885KMT2A 4681/4885NPC1 1994/4885 |
| US-20190292162-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | DHODH, DLD, THOC2 | MEN1 3352/4885KMT2A 4625/4885NPC1 420/4885 |
| US-20190290620-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING INFLAMMATORY BOWEL DISEASES | FABP2, SLC10A2, ALPI | MEN1 4844/4885KMT2A 4681/4885NPC1 1994/4885 |
| US-10919869-B2 | Thiazole derivative and applications | DHODH, DLD, THOC2 | MEN1 3352/4885KMT2A 4625/4885NPC1 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.