Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | KDM6B | O15054 | 3/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.48 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KDM5C | P41229 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM5A | P29375 | 2/20 | 0.48 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.48 |
| ▸ | TET3 | O43151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19632064 | 1.00 | MITF (0.51) | MITFSMN1; SMN2LMNAAGTR1OPRK1 | |
| SCHEMBL19617708 | 0.89 | NPC1 (0.52) | MITFSMN1; SMN2LMNAAGTR1OPRK1 | |
| SCHEMBL19632252 | 0.89 | NPC1 (0.52) | MITFSMN1; SMN2LMNAAGTR1OPRK1 | |
| SCHEMBL19631979 | 0.86 | KDM4E (0.51) | SMN1; SMN2LMNAHTTMRGPRX4KDM6B | |
| SCHEMBL19615732 | 0.86 | KDM4E (0.51) | SMN1; SMN2LMNAHTTMRGPRX4KDM6B | |
| SCHEMBL19631981 | 0.84 | CNR2 (0.53) | MITFSMN1; SMN2LMNAAGTR1OPRK1 | |
| SCHEMBL19632185 | 0.82 | KDM5C (0.61) | LMNAAGTR1KDM6BKDM4CKDM2A | |
| SCHEMBL19631866 | 0.82 | KDM5C (0.61) | LMNAAGTR1KDM6BKDM4CKDM2A | |
| SCHEMBL17858389 | 0.80 | SMN1; SMN2 (0.62) | MITFSMN1; SMN2LMNAAGTR1OPRK1 | |
| SCHEMBL19615728 | 0.80 | LMNA (0.52) | MITFSMN1; SMN2LMNAAGTR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |