Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | PYGM | P11217 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946681 | 0.79 | PYGL (0.36) | GRM4LRRK2GRM5CLK4PYGL | |
| SCHEMBL1853358 | 0.79 | ALDH1A1 (0.46) | KDM4EGRM4LRRK2GRM5CLK4 | |
| SCHEMBL3511033 | 0.79 | LRRK2 (0.40) | GRM4LRRK2GRM5CLK4PYGL | |
| SCHEMBL19278272 | 0.76 | GRM5 (0.37) | KDM4EGRM4HTTGRM5CLK4 | |
| SCHEMBL8284487 | 0.74 | KDM4E (0.55) | KDM4EMAPTKDM4C | |
| SCHEMBL6840488 | 0.74 | KDM4E (0.55) | KDM4EHTTLMNANOS3NOS1 | |
| SCHEMBL5936390 | 0.73 | KDM4C (0.55) | KDM4EGRM4LRRK2GRM5LMNA | |
| Water SCHEMBL347466 | 0.73 | KDM4C (0.55) | KDM4EGRM4LRRK2GRM5LMNA | |
| SCHEMBL16139802 | 0.73 | KDM4E (0.53) | KDM4EHTTGRM5LMNAMAPT | |
| SCHEMBL13593104 | 0.73 | KDM4E (0.53) | KDM4EGRM5MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |