⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349567 | 0.87 | XDH (0.32) | — | |
| SCHEMBL3349807 | 0.79 | PTGER4 (0.37) | — | |
| SCHEMBL8944385 | 0.78 | — | — | |
| SCHEMBL984963 | 0.77 | ENPP3 (0.38) | — | |
| SCHEMBL1665957 | 0.77 | FGFR1 (0.35) | — | |
| SCHEMBL13005142 | 0.76 | — | — | |
| SCHEMBL13005227 | 0.74 | — | — | |
| SCHEMBL3347458 | 0.72 | MGAM (0.41) | — | |
| SCHEMBL982198 | 0.69 | FFAR1 (0.36) | — | |
| SCHEMBL3229391 | 0.68 | PARP1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| US-8222416-B2 | Azaindole glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2012-07-17 | — | — | US | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| US-20110144105-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2011-06-16 | — | — | US | disclosed |