Sugi Predict

Sugi Predict / Compounds / SCHEMBL3347458

SCHEMBL3347458

SCHEMBL3347458

CC(C)(C)[Si](C)(C)n1ccc2cc(C(=O)O)cnc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MGAM O43451 1/20 0.41
▸ PSMD14 O00487 1/20 0.37
▸ HCAR3 P49019 3/20 0.33
▸ HPGD P15428 2/20 0.33
▸ P4HA1 P13674 2/20 0.33
▸ P4HTM Q9NXG6 2/20 0.33
▸ MIF P14174 1/20 0.33
▸ RXRA P19793 1/20 0.32
▸ GABRP O00591 1/20 0.32
▸ GABRD O14764 1/20 0.32
▸ GABRA1 P14867 1/20 0.32
▸ GABRB1 P18505 1/20 0.32
▸ GABRG2 P18507 1/20 0.32
▸ GABRB3 P28472 1/20 0.32
▸ GABRA5 P31644 1/20 0.32
▸ GABRA3 P34903 1/20 0.32
▸ GABRA2 P47869 1/20 0.32
▸ GABRB2 P47870 1/20 0.32
▸ GABRA4 P48169 1/20 0.32
▸ GABRE P78334 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2183148 0.80 HPGD (0.43) HPGDP4HTMALDH1A1LMNA
SCHEMBL222814 0.79 MGAM (0.42) MGAMPSMD14HCAR3HPGDP4HA1
SCHEMBL13004725 0.77 — —
SCHEMBL984963 0.77 ENPP3 (0.38) HSD17B10
SCHEMBL1050792 0.76 MGAM (0.47) MGAMPSMD14HCAR3HPGDP4HA1
SCHEMBL31571146 0.76 MGAM (0.47) MGAMPSMD14HCAR3HPGDP4HA1
SCHEMBL18993138 0.75 MGAM (0.41) MGAMPSMD14
SCHEMBL13005227 0.74 — —
SCHEMBL14822493 0.74 DGAT1 (0.45) MGAMPSMD14P4HA1P4HTMMIF
SCHEMBL878760 0.73 MGAM (0.47) MGAMPSMD14HCAR3HPGDP4HA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633750-B1 SYNTHESIS OF 5-SUBSTITUTED 7-AZAINDOLES AND 7-AZAINDOLINES EISAI R&D MAN CO LTD (JP) 2010-12-01 — — EP disclosed
EP-1633750-B1 SYNTHESIS OF 5-SUBSTITUTED 7-AZAINDOLES AND 7-AZAINDOLINES EISAI R&D MAN CO LTD (JP) 2010-12-01 — — EP disclosed
US-7652137-B2 Substitued azaindoline intermediate for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles; pharmaceutical intermediates EISAI R & D MANAGEMENT CO., LTD. (JP) 2010-01-26 — — US disclosed
US-7652137-B2 Substitued azaindoline intermediate for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles; pharmaceutical intermediates EISAI R & D MANAGEMENT CO., LTD. (JP) 2010-01-26 — — US disclosed
US-7652137-B2 Substitued azaindoline intermediate for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles; pharmaceutical intermediates EISAI R & D MANAGEMENT CO., LTD. (JP) 2010-01-26 — — US disclosed
WO-2008144253-A1 PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF IRM LLC (BM) 2008-11-27 — — WO disclosed
US-20060235042-A1 Synthesis EISAI CO., LTD. (JP) 2006-10-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060235042-A1 Synthesis AZI2, CYP3A5, CYP3A7 MGAM 3675/4885PSMD14 4030/4885HCAR3 3239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.