Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634396 | 0.94 | ERCC1 (0.38) | ERCC1ERCC4HDAC1TPSAB1PLG | |
| SCHEMBL19634408 | 0.88 | ERCC1 (0.40) | ERCC1ERCC4HDAC1TPSAB1PLG | |
| SCHEMBL23471107 | 0.86 | KMT2A (0.49) | HDAC1HDAC6KMT2AEPHX2NR1H4 | |
| SCHEMBL21015966 | 0.86 | ERCC1 (0.41) | ERCC1ERCC4KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL19634395 | 0.85 | MLYCD (0.46) | ERCC1ERCC4HDAC1HDAC6EPHX2 | |
| SCHEMBL19634695 | 0.83 | ERCC1 (0.49) | ERCC1ERCC4HDAC1HDAC6KMT2A | |
| SCHEMBL21015207 | 0.83 | HDAC6 (0.50) | HDAC1HDAC6KMT2AEPHX2NR1H4 | |
| SCHEMBL19634735 | 0.81 | ERCC1 (0.37) | ERCC1ERCC4KMT2A | |
| SCHEMBL19634399 | 0.81 | ERCC1 (0.44) | ERCC1ERCC4HDAC1HDAC6KMT2A | |
| SCHEMBL23471020 | 0.81 | KMT2A (0.43) | HDAC1HDAC6KMT2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |