Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.60 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.60 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21851808 | 0.92 | SIGMAR1 (0.71) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| SCHEMBL1088446 | 0.87 | SIGMAR1 (0.74) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| Bromide SCHEMBL10673628 | 0.86 | CARM1 (0.62) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| Hydrochloric Acid SCHEMBL1087168 | 0.85 | SIGMAR1 (0.71) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| SCHEMBL7225346 | 0.85 | SIGMAR1 (0.85) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| SCHEMBL29733117 | 0.85 | SIGMAR1 (0.85) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| SCHEMBL6028050 | 0.85 | SIGMAR1 (0.61) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| SCHEMBL7055109 | 0.83 | CARM1 (0.75) | SIGMAR1LMNACARM1PRMT6PRMT8 | |
| SCHEMBL2949711 | 0.82 | SIGMAR1 (0.85) | SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL12359495 | 0.82 | SIGMAR1 (0.67) | SIGMAR1LMNACARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |