SCHEMBL7225346

SCHEMBL7225346

CN(CCCCCCCCCCN(C)Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.85

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.85
MAOB P27338 4/20 0.67
CARM1 Q86X55 1/20 0.67
PRMT6 Q96LA8 1/20 0.67
PRMT8 Q9NR22 1/20 0.67
MAOA P21397 1/20 0.67
ACHE P22303 5/20 0.63
KDM4A O75164 2/20 0.59
KDM4C Q9H3R0 2/20 0.59
LMNA P02545 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29733117 1.00 SIGMAR1 (0.85) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL16260101 0.94 SIGMAR1 (0.76) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL1088446 0.93 SIGMAR1 (0.74) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL7190739 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL2326491 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL9131293 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL10352566 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL278595 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL9275367 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8
SCHEMBL15966143 0.92 SIGMAR1 (0.73) SIGMAR1MAOBCARM1PRMT6PRMT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6576791-B1 Local anesthetic compounds and uses THERAVANCE, INC. 2003-06-10 US disclosed
US-6495681-B1 PRODUCING LOCAL ANESTHESIA OF LONG-DURATION. THE COMPOUNDS OF THIS INVENTION ARE MULTIBINDING COMPOUNDS THAT COMPRISE FROM 2 TO 10 LIGANDS COVALENTLY ATTACHED TO A LINKER OR LINKERS, EACH LIGAND BEING CAPABLE OF BINDING TO A LIGAND BINDING SITE THERAVANCE INC. 2002-12-17 US disclosed
US-6462034-B1 MULTIBINDING COMPOUNDS CONTAINING A SYMETRICAL DIAMINOTETRA-ETHERDODECANE RING WITH TWO SECONDARY AMIDE AND ADDITIONAL SUBSTITUENTS; VOLTAGE GATED SODIUM CHANNEL MODULATORS; LONG DURATION THERAVANCE, INC. 2002-10-08 US disclosed
US-6337423-B1 BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY ADVANCED MEDICINE, INC. 2002-01-08 US disclosed
EP-1066245-A4 NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES ADVANCED MEDICINE INC (US) 2001-01-24 EP disclosed
EP-1066245-A1 NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES Advanced Medicine, Inc. (US) 2001-01-10 EP disclosed
WO-1999051565-A9 NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES ADVANCED MEDICINE INC (US) 1999-12-02 WO disclosed
WO-1999051565-A1 NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES ADVANCED MEDICINE, INC. (US) 1999-10-14 WO disclosed