Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.51 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 5/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21851808 | 0.92 | SIGMAR1 (0.71) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL10655267 | 0.92 | SIGMAR1 (0.71) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL7435010 | 0.92 | SIGMAR1 (0.71) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL10925712 | 0.92 | SIGMAR1 (0.71) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL4016132 | 0.92 | SIGMAR1 (0.71) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL10650528 | 0.90 | SIGMAR1 (0.68) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL19635145 | 0.85 | SIGMAR1 (0.65) | SIGMAR1MAOBMAOATMEM97ACHE | |
| SCHEMBL5744436 | 0.85 | SIGMAR1 (0.65) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| Hydrochloric Acid SCHEMBL27998890 | 0.83 | SIGMAR1 (0.62) | SIGMAR1MAOBMAOATMEM97KDM4A | |
| SCHEMBL7225346 | 0.83 | SIGMAR1 (0.85) | SIGMAR1MAOBMAOAKDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633707-A1 | 1- (ALKYLAMINOALKYL-PYROLIDIN-/PIPERIDINYL) -2, 2-DIPHENYLACETAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2005123670-A2 | CRYSTALLINE FORM OF A SUBSTITUTED PYRROLIDINE COMPOUND | THERAVANCE, INC. (US) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005003090-A1 | 1- (ALKYLAMINOALKYL-PYROLIDIN-/PIPERIDINYL) -2, 2-DIPHENYLACETAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-01-13 | — | — | WO | disclosed |