Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.55 |
| ▸ | VHL | P40337 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22087714 | 0.91 | KRAS (0.47) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21895551 | 0.78 | KRAS (0.33) | KRAS | |
| SCHEMBL22087290 | 0.78 | KRAS (0.36) | KRAS | |
| SCHEMBL21912130 | 0.78 | KRAS (0.36) | KRAS | |
| SCHEMBL24459902 | 0.78 | KRAS (0.69) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL23465147 | 0.78 | KRAS (0.69) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL24459962 | 0.78 | KRAS (0.62) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19947678 | 0.77 | KRAS (0.70) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL25716332 | 0.77 | KRAS (0.67) | KRAS | |
| SCHEMBL25716330 | 0.77 | KRAS (0.67) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |