Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21895574 | 0.74 | KRAS (0.39) | — | |
| SCHEMBL19637079 | 0.71 | HTT (0.32) | HPGDTLR7 | |
| SCHEMBL21895629 | 0.69 | KRAS (0.38) | — | |
| SCHEMBL19637432 | 0.68 | KDM4E (0.36) | — | |
| SCHEMBL21230439 | 0.64 | GBA1 (0.39) | — | |
| SCHEMBL25668002 | 0.64 | GBA1 (0.39) | — | |
| SCHEMBL13193523 | 0.64 | GBA1 (0.39) | — | |
| SCHEMBL12912378 | 0.63 | CYP2D6 (0.48) | TLR7 | |
| SCHEMBL19637255 | 0.63 | HTT (0.34) | HPGD | |
| SCHEMBL15133969 | 0.62 | DRD2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |