Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639698 | 0.87 | MAPT (0.43) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL19639684 | 0.83 | MEN1 (0.47) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL19639664 | 0.76 | KMT2A (0.46) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL17753760 | 0.71 | MAPT (0.45) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL5888030 | 0.70 | MEN1 (0.46) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL5888033 | 0.70 | MEN1 (0.46) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL6418177 | 0.70 | MEN1 (0.49) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL5124855 | 0.70 | ALDH1A1 (0.51) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL6418180 | 0.70 | MEN1 (0.49) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 | |
| SCHEMBL6760015 | 0.70 | SMN1; SMN2 (0.49) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRD3 | ALDH1A1 1563/4885CYP1A2 3848/4885MAPK1 662/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | ALDH1A1 1563/4885CYP1A2 3848/4885MAPK1 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.