Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17753760 | 0.86 | MAPT (0.45) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL19639665 | 0.83 | ALDH1A1 (0.51) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL5888030 | 0.82 | MEN1 (0.46) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL5888033 | 0.82 | MEN1 (0.46) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL6418177 | 0.81 | MEN1 (0.49) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL6418180 | 0.81 | MEN1 (0.49) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL19639664 | 0.78 | KMT2A (0.46) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL30737053 | 0.76 | KMT2A (0.59) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL6760015 | 0.74 | SMN1; SMN2 (0.49) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL20512748 | 0.73 | MEN1 (0.44) | MEN1KMT2ACYP1A2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRD3 | MEN1 1364/4885KMT2A 165/4885CYP1A2 3848/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | MEN1 1364/4885KMT2A 165/4885CYP1A2 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.